Do you know the secret of Mona Lisa’s smile? Did you know that when Newton discovered how the prism broke up light into various colors, Vermeer, too, was studying light in his paintings? Do you know when it comes to vision, what you see first? Do you know why we often think of science and art as two different areas of study? This talk takes you from the 14th century to today, as we explore how science and art depend on each other in terms of paint itself, light, mathematics, physics, and brain science.